2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B1834S1
    Megestrol-d5
    Megestrol-d5 is the deuterium labeled Megestrol. Megestrol is a synthetic progestin and used for the treatment of anorexia, cachexia, or an unexplained significant weight loss in patients with an acquired immunodeficiency syndrome diagnosis.
    Megestrol-d<sub>5</sub>
  • HY-N7177
    Hydroxytanshinone IIA
    Hydroxytanshinone IIA is a hydroxylated metabolite of Tanshinone IIA. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2.
    Hydroxytanshinone IIA
  • HY-128459
    N-Demethylerythromycin A
    N-Demethylerythromycin A is a metabolite of Erythromycin A. Erythromycin A is an antibiotic.
    N-Demethylerythromycin A
  • HY-137152
    8-Aminoclonazolam
    8-Aminoclonazolam is a benzodiazepine and clonazolam metabolite.
    8-Aminoclonazolam
  • HY-U00199S
    N-Desmethyl zopiclone-d8
    N-Desmethyl zopiclone-d8 is deuterium labeled Norzopiclone. Norzopiclone is the inactive metabolite of Zopiclone. Norzopiclone has some anxiolytic properties.
    N-Desmethyl zopiclone-d<sub>8</sub>
  • HY-W776973
    Glycidamide-13C3
    Glycidamide-13C3 (Oxiranecarboxamide-13C3) is the 13C-labeled Glycidamide (HY-119329). Glycidamide is the genotoxic metabolite of Acrylamide. Glycidamide can react with proteins, such as hemoglobin, or with DNA, and induces genotoxic effects.
    Glycidamide-<sup>13</sup>C<sub>3</sub>
  • HY-134242
    6-T-5'-GMP disodium
    6-T-5'-GMP disodium is an analogue of guanosine-5'-O-monophosphate (5'-GMP) and a metabolite of an immunosuppressive drug, azathioprine (HY-B0256).
    6-T-5'-GMP disodium
  • HY-B1069R
    Molsidomine (Standard)
    Molsidomine (Standard) (SIN-10 (Standard)) is the analytical standard of Molsidomine (HY-B1069). This product is intended for research and analytical applications. Molsidomine, a nitric oxide (NO) donor, is an orally active vasodilator agent. Molsidomine is a prodrug that can be rapidly metabolized in the liver to its active metabolite, Linsidomine (HY-101200). Molsidomine can be used for the study of angina pectoris, mental disorders and diabetic complications.
    Molsidomine (Standard)
  • HY-135328
    Norverapamil
    Norverapamil ((±)-Norverapamil), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.
    Norverapamil
  • HY-137932
    Resveratrol-3-O-sulfate sodium
    Resveratrol-3-O-sulfate (sodium) is the metabolite of Resveratrol.
    Resveratrol-3-O-sulfate sodium
  • HY-139199
    4-Hydroxyphenylbutazone
    4-Hydroxyphenylbutazone is a metabolite of Phenylbutazone. Phenylbutazone, a nonsteroidal anti-inflammatory agent (NSAID), is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS).
    4-Hydroxyphenylbutazone
  • HY-W709612
    Regorafenib N-oxide and N-desmethyl (M5)-d3-1
    Regorafenib N-oxide and N-desmethyl (M5)-d3-1 (N-Desmethyl regorafenib N-oxide-d3-1) is the deuterium labeled Regorafenib N-oxide and N-desmethyl (M5) (HY-108226). Regorafenib N-oxide and N-desmethyl (M5) (N-Desmethyl regorafenib N-oxide) is an active metabolite of Sorafenib (HY-10201) and can be metabolized by CYP3A4.
    Regorafenib N-oxide and N-desmethyl (M5)-d<sub>3</sub>-1
  • HY-G0007R
    Omeprazole sulfone (Standard)
    Omeprazole sulfone (Standard) is the analytical standard of Omeprazole sulfone. This product is intended for research and analytical applications.
    Omeprazole sulfone (Standard)
  • HY-134670
    a-Hydroxymetoprolol
    a-Hydroxymetoprolol is a metabolite of metoprolol. The adrenoreceptor blocking effect of a-Hydroxymetoprolol on metoprolol is almost zero.
    a-Hydroxymetoprolol
  • HY-100243A
    Norcisapride
    Norcisapride is a metabolite of cisapride (HY-14149). Norcisapride can be converted into UNK under CYP3A4.
    Norcisapride
  • HY-118816
    11β-Prostaglandin F2α
    11β-Prostaglandin F2α ethanolamide (11β-PGF2α-EA) is the theoretical hepatic metabolite of PGD2-EA, produced during COX-2 metabolism of the endogenous cannabinoid AEA which is found in brain, liver, and other mammalian tissues.1 AEA can be used directly by COX-2 and specific PG synthase to produce ethanolamide congeners of the classical PGs. PGD2-EA is formed in activated RAW 264.7 cells treated with AEA.
    11β-Prostaglandin F2α
  • HY-135161
    EDDP perchlorate
    EDDP perchlorate is an N-desmethyl metabolite of Methadone by intestinal, hepatic, and cytochrome P450 (CYP) 3A4.
    EDDP perchlorate
  • HY-137324
    α-Apooxytetracycline
    α-Apooxytetracycline is a degradation product of Oxytetracycline (HY-B0275). Oxytetracycline is an antibiotic belonging to the tetracycline class.
    α-Apooxytetracycline
  • HY-W662579
    N-Desmethyl clotiazepam
    N-Desmethyl clotiazepam (Desmethylclotiazepam) is an active metabolite of Clotiazepam.
    N-Desmethyl clotiazepam
  • HY-N0176A
    α-Dihydroartemisinin
    α-Dihydroartemisinin (α-Dihydroqinghaosu; α-Artenimol) is a antimalarial agent that can be found in Artemisia annua L.
    α-Dihydroartemisinin
Cat. No. Product Name / Synonyms Application Reactivity